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Items for the Week: COPD
A Risk Factor for Type 2 Diabetes
on Tuesday,
October 12 @ 14:18:44 EDT
"Inflammation plays a key
role in COPD and asthma."
Chronic
obstructive pulmonary disease (COPD), but not
asthma, may be a risk factor for the development
of type 2 diabetes.
"Inflammation plays a key
role in COPD and asthma," Dr. Carlos A. Camargo,
Jr. of the Channing Laboratory in Boston and
colleagues write. "Increasing evidence points
toward a role of inflammation in the pathogenesis
of type 2 diabetes."
The researchers
examined the association between COPD and asthma
and the development of type 2 diabetes among
participants in the Nurses' Health Study. A total
of 103,614 female nurses completed questionnaires
every 2 years from 1988 to 1996 to update
information on newly diagnosed emphysema, chronic
bronchitis, asthma, and diabetes.
A total
of 2959 new cases of type 2 diabetes were
documented during 8 years of follow-up. Patients
with COPD were significantly more likely to
develop type 2 diabetes than those without COPD
(multivariate relative risk 1.8).
In
contrast, the asthmatic patients did not have a
significantly increased risk of type 2 diabetes
(multivariate relative risk 1.0).
Additional
prospective studies are needed to investigate the
relationship between these two conditions and to
"examine cytokine profiles (both Th1 and Th2) in
COPD or asthmatic patients who go on to develop
type 2 diabetes," Dr. Camargo's group
adds.
"Moreover, future prospective studies
might examine whether COPD or asthma are
associated with increased risk of other diseases
with an inflammatory component, such as
atherosclerosis."
Diabetes Care
2004;27:2478-2484.
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FACT:
''In the next 10 years, 80
percent of all heart disease will be due to type 2
diabetes."
Dr. Heber, director of UCLA's
Center for Human
Nutrition
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Average Score: 3.75
Votes:
16
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